Miscellaneous Agents & Vaccines Flashcards

Explore a variety of high-yield medications and common vaccines tested on the NAPLEX. (26 cards)

1
Q

What is the common brand name(s) for:

bimatoprost ophthalmic

(bi-MAT-oh-prost off-THAL-mik)

A

Lumigan

Class: Prostaglandin, Antiglaucoma

Indication: Elevated intraocular pressure; hypotrichosis of the eyelashes

MOA: Synthetic prostaglandin increases aqueous humor outflow; decreasing intraocular pressure

Side effects: eye discoloration; discomfort; inflammation; Hypertrichosis; dry eyes

Contraindications: Active ocular inflammation; recent ocular surgery or trauma

Considerations:

  • Remove contact lenses prior to application and wait at least 15 minutes before reinserting them.

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2
Q

What is the common brand name(s) for:

brimonidine

(bri-MOE-ni-deen)

A

Alphagan P

Class: Antiglaucoma, Alpha-2 adrenoceptor agonist

Indication: Postoperative control of intraocular pressure; open-angle glaucoma; ocular hypertension

MOA: Decreases aqueous humor formation (alpha2)

Side effects: drowsiness; allergic conjunctivitis; xerostomia; erythema of eyelid; blood pressure changes

Contraindications: Infants and young children

Considerations:

  • Patients should remove contact lenses prior to instillation and wait approximately 15 minutes before reinserting them.

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3
Q

What is the common brand name(s) for:

clobetasol

(kloe-BAY-ta-sol)

A

Temovate

Class: Topical corticosteroid

Indication: Psoriasis; eczema; dermatitis; lichen planus

MOA: Binds to glucocorticoid receptors; altering gene expression to suppress inflammation

Side effects: skin atrophy; striae; telangiectasia; hypopigmentation; acne eruptions; irritation

Contraindications: Cutaneous infections, areas with thin skin

Considerations:

  • Intended for short-term use (typically 2 weeks or less) to minimize risk of side effects.

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4
Q

What is the common brand name(s) for:

cyclosporine ophthalmic

(sye-kloe-SPOR-een off-THAL-mik)

A

Restasis

Class: Ocular Immunomodulator

Indication: Chronic dry eye disease; ocular surface inflammation

MOA: Suppresses T-cell activation; reducing inflammatory mediators on the ocular surface

Side effects: ocular burning or stinging; redness; blurry vision; foreign body sensation

Contraindications: Hypersensitivity to drug or its components.

Considerations:

  • Typically instilled twice daily.
  • Improvement may take weeks to months.
  • Use caution in pregnant or lactating patients.

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5
Q

What is the common brand name(s) for:

fluocinonide

(floo-oh-SIN-oh-nide)

A

Lidex

Class: Topical corticosteroid

Indication: Psoriasis; eczema; dermatitis

MOA: Binds to glucocorticoid receptors; modulating gene expression to reduce inflammation

Side effects: skin atrophy; striae; telangiectasia; changes in skin pigmentation; irritation

Contraindications: Hypersensitivity to drug or its components.

Considerations:

  • Intended for short-term use (about 2 weeks).

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6
Q

What is the common brand name(s) for:

hydrocortisone

(hye-droe-KOR-ti-sone)

A

Cortizone

Class: Glucocorticoid

Indication: Adrenal insufficiency; thyroid storm; anaphylaxis; corticosteroid replacement therapy; IBD; eczema; asthma; nappy rash; hypersensitivity reactions; oral/perioral lesions

MOA: Binds to glucocorticoid receptors, decreasing inflammation and providing immunosuppressive effects.

Side effects: anxiety; Cushing’s syndrome; osteoporosis; fatigue; hirsutism; nausea; increased appetite; cardiac failure; vertigo; adrenal suppression; hypertension

Contraindications: Acne; rosacea; untreated infections

Considerations:

  • Salt-retaining activity due to mineralocorticoid effects.
  • Fludrocortisone may be needed for adrenal insufficiency.
  • Avoid long-term use; taper to avoid adrenal crisis.
  • Monitor for secondary infections; osteoporosis; fat redistribution.
  • Caution in elderly due to psychiatric effects.
  • Monitor height in children on long-term therapy.

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7
Q

What is the common brand name(s) for:

imiquimod

(i-MIK-wi-mod)

A

Aldara

Class: Immune response modifier

Indication: External genital warts; actinic keratoses; superficial basal cell carcinoma

MOA: Binds to TLR7; triggering cytokine production for immune-mediated attack on abnormal cells

Side effects: erythema; edema; irritation; burning; itching; stinging; erosion; scabbing

Contraindications: Hypersensitivity to drug or its components

Considerations:

  • Caution in pregnant or lactating women.
  • Caution in individuals with compromised immune systems or autoimmune conditions.

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8
Q

What is the common brand name(s) for:

latanoprost

(la-TAN-oh-prost)

A

Xalatan

Class: Prostaglandin, Antiglaucoma

Indication: Open-angle glaucoma

MOA: Increases aqueous humor outflow via the uveoscleral pathway

Side effects: permanent eye color change; erythema of eyelid; eye discomfort; hyperemia; increased eyelash length

Contraindications: Hypersensitivity to drug or its components

Considerations:

  • Administered once daily.
  • Remove contact lenses before instillation and wait 15 minutes before reinsertion.

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9
Q

What is the common brand name(s) for:

tacrolimus

(ta-KROE-li-mus)

A

Protopic

Class: Calcineurin Inhibitor

Indication: Autoimmune diseases; organ transplant rejection prophylaxis; graft vs host disease prevention; rheumatoid arthritis; myasthenia gravis; nephrotic syndrome

MOA: Inhibits calcineurin; preventing T-cell activation and formation

Side effects: increased infection risk; pure red cell aplasia; hyperkalemia; hypertension; cardiac effects; hypersensitivity reactions; renal dysfunction; neurotoxicity; increased malignancy risk; GI perforation

Contraindications: Allergy to castor oil

Considerations:

  • Monitor tacrolimus levels and renal function.
  • Use lowest dose in renal or hepatic impairment.

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10
Q

What is the common brand name(s) for:

timolol

(TIM-oh-lol)

A

Timoptic

Class: Antiglaucoma, beta blocker

Indication: Open-angle glaucoma; hypertension; MI prevention; migraine prevention

MOA: Non-selective beta-adrenergic antagonist; may block vasodilation and reduce platelet aggregation

Side effects: eye discomfort; visual disorders; systemic effects like abdominal discomfort; bradycardia; breathlessness.

Contraindications: Bronchial asthma; severe COPD; sinus bradycardia; heart block; cardiogenic shock

Considerations:

  • Caution in asthma; COPD.

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11
Q

What is the common brand name(s) for:

travoprost

(TRAV-oh-prost)

A

Travatan

Class: Prostaglandin, Antiglaucoma

Indication: Open-angle glaucoma; ocular hypertension

MOA: Increases aqueous humor outflow; decreasing intraocular pressure

Side effects: eye discoloration; discomfort; inflammation; hypertension; hypertrichosis; dry eyes.

Contraindications: Hypersensitivity to drug or its components

Considerations:

  • Remove contact lenses before application and wait 15 minutes before reinsertion.

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12
Q

What is the common brand name(s) for:

triamcinolone

(trye-AM-sin-oh-lone)

A

Kenalog

Class: Glucocorticoid

Indication: Allergic rhinitis; local joint inflammation; suppresses inflammation

MOA: Inhibits phospholipase A2; decreasing leukotriene and prostaglandin production

Side effects: epistaxis; headache; throat irritation; altered sense of smell; rare glaucoma; blurred vision

Contraindications: Active infection

Considerations:

  • Caution with large or chronic topical application.
  • Intra-articular injection may cause hyperglycemia.
  • Avoid long-term use; taper to avoid adrenal crisis.
  • Monitor for secondary infections; osteoporosis; fat redistribution.
  • Caution in elderly due to psychiatric effects.
  • Monitor height in children on long-term therapy.

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13
Q

What is the common brand name(s) for:

inactivated polio vaccine

(in-AK-ti-vay-ted POE-lee-oh vak-SEEN)

A

IPOL

Class: Inactivated viral vaccine

Indication: Poliovirus prevention

MOA: Induces active immunity against poliovirus types 1, 2, and 3

Side effects: anorexia; swelling at injection site; fatigue; irritability; vomiting; fever

Contraindications: Anaphylaxis occurring within 24 hours of administration of one dose of vaccine; acute febrile illness

Considerations:

  • Administered via intramuscular injection.
  • Standard schedule—injections typically starting at 2 months of age, with additional doses at 4 and 6 to 8 months, followed by booster doses in later childhood.

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14
Q

What is the common brand name(s) for:

rabies vaccine

(RAY-beez vak-SEEN)

A

Imovax Rabies, Rabavert

Class: Inactivated rabies vaccine

Indication: Preexposure and postexposure vaccination against rabies

MOA: Promotes immunity by inducing an active immune response

Side effects: lymphadenopathy; pain at injection site; dizziness; headache; myalgia

Contraindications: Hypersensitivity to drug or any of its components

Considerations:

  • Antibody production takes 7–10 days; peak effect is 30–60 days.
  • Watch for syncope with injection.
  • Caution in patients with bleeding disorders.

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15
Q

What is the common brand name(s) for:

yellow fever vaccine

(YEL-oh FEE-ver vak-SEEN)

A

YF-VAX

Class: Live attenuated viral vaccine

Indication: Yellow fever prevention

MOA: Active immunization against yellow fever infection

Side effects: headache; malaise; fever; skin rash

Contraindications: Hypersensitivity to egg or chick embryo protein; infants younger than 9 months (including in breast milk); severely immunocompromised patients (HIV; leukemia; general malignancy)

Considerations:

  • Seroconversion is 10–14 days.
  • Response rate of nearly 100% in patients.
  • Monitor for hypersensitivity and syncope 15 minutes after administration.

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16
Q

What is the common brand name(s) for:

varicella virus vaccine live

(va-ri-SELL-a VYE-rus vak-SEEN lyv)

A

Varivax, Zostavax

Class: Live attenuated viral vaccine

Indication: Varicella prevention in persons 12 months and older

MOA: Active immunity to disease caused by the varicella-zoster virus

Side effects: injection site reaction; fever; skin rash; abdominal pain; diarrhea; nausea; arthralgia

Contraindications: Anaphylactic reaction to neomycin and gelatin; immunosuppressed or immunodeficient; untreated tuberculosis (TB); active fever; pregnant or planning to become pregnant within next 3 months

Considerations:

  • Varivax used to prevent chickenpox; Zostavax used to prevent reactivation of the virus causing shingles.
  • Varivax for 12 months and older.
  • Shingrix is similar to Zostavax but is a recombinant subunit vaccine (more effective vaccination profile).

17
Q

What is the common brand name(s) for:

pneumococcal vaccine 20-valent

(noo-moe-KOK-al vak-SEEN TWEN-tee VAY-lent)

A

Prevnar 20

Class: Inactivated bacterial vaccine

Indication: Invasive streptococcus pneumoniae prevention; otitis media prevention; pneumococcal disease prevention

MOA: Promotes active immunization against pneumonia and invasive disease caused by S. pneumoniae

Side effects: injection site reaction; fatigue; headache; arthralgia; fever

Contraindications: Hypersensitivity to drug or any of its components

Considerations:

  • Approved for use in adults 18 years and older.
  • Current guidelines suggest that Prevnar 20 may be used as a stand-alone vaccine in many adult populations without the need for sequential dosing with pneumococcal polysaccharide vaccines (such as PPSV23); although vaccination history and specific risk factors should be taken into account.

18
Q

What is the common brand name(s) for:

pneumococcal vaccine 23-valent

(noo-moe-KOK-al vak-SEEN TWEN-tee-three VAY-lent)

A

Pneumovax 23

Class: Inactivated bacterial vaccine

Indication: Pneumococcal disease prevention

MOA: Induces active immunization against S. pneumoniae

Side effects: injection site reaction; fatigue; headache; arthralgia; fever

Contraindications: Hypersensitivity to drug or any of its components

Considerations:

  • For 2 years and older at increased risk and those 50 years and older to prevent pneumococcal disease.
  • Monitor for hypersensitivity and syncope 15 minutes after administration.

19
Q

What is the common brand name(s) for:

diphtheria and tetanus toxoids and acellular pertussis vaccine
(DTaP)

(dif-THEER-ee-uh and TET-uh-nus TOK-soydz and ay-SELL-yoo-ler per-TUSS-is vak-SEEN)

A

Adacel, Boostrix, Daptacel, Infanrix

Class: Inactivated bacterial vaccine

Indication: Prevention of diphtheria; tetanus; and pertussis

MOA: Promotes active immunity through the production of specific antibodies

Side effects: anorexia; swelling at injection site; fatigue; irritability; vomiting; fever; drowsiness; lethargy

Contraindications: Progressive neurologic disorder (Infanrix only); encephalopathy within 7 days of a previous pertussis-containing vaccine dose; children/adults 7 or older (Daptacel only)

Considerations:

  • DTaP vaccines for infants and children.
  • Tdap vaccines for adolescents; pregnant women; and adults for booster.

20
Q

What is the common brand name(s) for:

measles, mumps, and rubella virus vaccine
(MMR)

(MEE-zulz, MUMPS, and roo-BELL-uh VY-rus vak-SEEN)

A

M-M-R II, Priorix

Class: Live vaccine

Indication: Prevention of measles; mumps; and rubella

MOA: Live, attenuated vaccine stimulating immunity

Side effects: anorexia; swelling at injection site; drowsiness; fever; rash; arthralgia; neck stiffness; diarrhea; nausea; angioedema

Contraindications: Active febrile illness; untreated tuberculosis; immunosuppressed/immunodeficient; pregnant or planning to become pregnant in the next month

Considerations:

  • Some dosage forms may contain human albumin; eggs; gelatin; latex.
  • Some products may be manufactured with neomycin.
  • Rubella vaccine virus can be detected in the nose and throat of vaccinated individuals for 7–28 days after vaccination.

21
Q

What is the common brand name(s) for:

hepatitis B vaccine

(hep-uh-TY-tis BEE vak-SEEN)

A

Engerix-B, Recombivax HB

Class: Inactivated viral vaccine

Indication: Prevention of hepatitis B

MOA: Noninfectious subunit viral vaccine that stimulates active immunity via formation of antihepatitis B antibodies

Side effects: soreness at injection site; fatigue; decreased appetite; diarrhea; nausea; dizziness; headache; pharyngitis; flushing; hypotension; vomiting; stomach cramps

Contraindications: Hypersensitivity to drug or any of its components

Considerations:

  • Multiple sclerosis exacerbations have been reported – use caution.
  • Older adults (greater than 60 years of age) may have lower response rates.

22
Q

What is the common brand name(s) for:

hepatitis A vaccine

(hep-uh-TY-tis AY vak-SEEN)

A

Havrix, Vaqta

Class: Inactivated viral vaccine

Indication: Prevention of hepatitis A

MOA: Inactivated virus vaccine to induce active immunity against hepatitis A virus

Side effects: drowsiness; headache; irritability; decreased appetite; erythema at injection site; weakness; fever; chills; fatigue; rash; abdominal pain; anorexia

Contraindications: Hypersensitivity to drug or any of its components

Considerations:

  • Some components include neomycin – use caution in those with a sensitivity.
  • Those with hepatic impairment may have decreased antibody response.

23
Q

What is the common brand name(s) for:

haemophilus influenzae type B vaccine

(HEE-moh-fil-us in-FLOO-en-zuh type BEE vak-SEEN)

A

Pedvax HIB

Class: Inactivated bacterial vaccine

Indication: Prevention of invasive disease caused by haemophilus influenzae type b

MOA: Stimulates production of anticapsular antibodies and provides active immunity

Side effects: anorexia; erythema at injection site; drowsiness; fever; rash; vomiting; pneumonia

Contraindications: Hypersensitivity to drug or any of its components

Considerations:

  • Some products may contain lactose or latex.

24
Q

What is the common brand name(s) for:

rotavirus vaccine

(ROE-tuh-vy-rus vak-SEEN)

A

Rotarix, RotaTeq

Class: Live vaccine

Indication: Prevention of rotavirus gastroenteritis

MOA: Live vaccine that replicates in the small intestine, promoting active immunity to rotavirus serotypes G1, G2, G3, G4, and G9

Side effects: diarrhea; vomiting; irritability; flatulence; bronchospasm; seizure

Contraindications: History of uncorrected congenital malformation of the GI tract; history of intussusception; severe combined immunodeficiency disease

Considerations:

  • Rotarix is not active against serotype G2.
  • Use caution in infants with any type of GI illness.
  • Not intended for use in adults.

25
# What is the common brand name(s) for: human papillomavirus vaccine | (HYOO-mun pap-ih-LOH-muh-vy-rus vak-SEEN)
Gardasil 9 | Class: Inactivated viral vaccine ## Footnote **Indication:** Prevention of human papillomavirus infection **MOA:** Produces neutralizing antibodies against HPV proteins **Side effects:** pain at injection site; headache; diarrhea; nausea; abdominal pain; dizziness; fatigue **Contraindications:** Hypersensitivity to drug or any of its components **Considerations:** * Intended to help prevent cervical, vulvar, vaginal, and anal cancers; cervical adenocarcinoma; cervical, vaginal, vulvar, and anal neoplasia; and genital warts caused by HPV.
26
# What is the common brand name(s) for: COVID-19 Vaccine *(mRNA)* | (KOH-vid nineteen vak-SEEN [em-ahr-ay-nay])
Comirnaty | Class: mRNA vaccine ## Footnote **Indication:** Prevention of COVID-19 **MOA:** Promotes active immunization against COVID-19 by formulating modified mRNA into lipid particles, allowing expression of the SARS-CoV-2 spike antigen **Side effects:** anaphylaxis; angioedema; nausea; rash; pain at injection site; myocarditis; pericarditis; irritability; fatigue; fever; headache **Contraindications:** Hypersensitivity to drug or any of its components **Considerations:** * If myocarditis or pericarditis develops within 3 weeks after any dose, subsequent doses are not generally recommended.