What protein in red blood cells is responsible for transporting oxygen in the blood?
Haemoglobin
A globular protein with a quaternary structure that binds oxygen reversibly.
Which cells in the blood are specialised for carrying oxygen around the body?
Red blood cells
Also called erythrocytes; they contain haemoglobin and lack a nucleus in mammals.
What is the name of the curve that shows the percentage saturation of haemoglobin with oxygen at different partial pressures of oxygen?
Oxyhaemoglobin dissociation curve
Demonstrates how readily haemoglobin loads and unloads oxygen under different conditions.
What property of haemoglobin means that the binding of the first oxygen molecule increases the affinity for additional oxygen molecules?
Cooperative binding
Caused by a conformational change in haemoglobin after the first oxygen binds.
How does increasing carbon dioxide concentration affect the affinity of haemoglobin for oxygen?
Decreases
This shift promotes oxygen release in respiring tissues.
What term describes the effect of carbon dioxide concentration on the dissociation of oxyhaemoglobin?
Bohr effect
Higher CO2 lowers haemoglobin affinity for oxygen, aiding oxygen delivery to tissues.
True or False:
The oxyhaemoglobin dissociation curve is linear because each oxygen molecule binds independently.
False
The curve is sigmoidal due to cooperative binding between haemoglobin subunits.
Why do animals living in low-oxygen environments often possess different types of haemoglobin?
They have different oxygen affinity.
Adapted haemoglobins bind oxygen more readily when oxygen availability is low.
Which blood vessels supply oxygenated blood directly to the heart muscle?
Coronary arteries
These branch from the aorta and provide the heart’s own oxygen supply.
Which blood vessel carries deoxygenated blood from the body into the right atrium?
Vena cava
Includes the superior and inferior vena cava.
Which artery carries deoxygenated blood from the heart to the lungs?
Pulmonary artery
The only artery that normally carries deoxygenated blood.
Which vein carries oxygenated blood from the lungs to the heart?
Pulmonary vein
Returns oxygenated blood to the left atrium.
What term describes the volume of blood pumped by one ventricle of the heart per beat?
Stroke volume
Usually measured in cm3 per beat.
What term describes the volume of blood pumped by the heart per minute?
Cardiac output
Calculated as stroke volume × heart rate.
Fill in the blank:
Cardiac output equals stroke volume multiplied by ______.
heart rate
CO = stroke volume × heart rate.
What structure in the heart prevents backflow of blood during the cardiac cycle?
Valves
Include atrioventricular valves and semilunar valves.
True or False:
During ventricular systole, the semilunar valves open to allow blood to leave the heart.
True
Blood is ejected into the aorta and pulmonary artery.
Which type of blood vessel has thick muscular walls and elastic fibres to withstand high pressure?
Arteries
Their elastic tissue allows stretching and recoil during the cardiac cycle.
Which small blood vessels control the distribution of blood to capillary beds?
Arterioles
Smooth muscle in their walls allows vasoconstriction and vasodilation.
Which type of blood vessel contains valves that help return blood to the heart?
Veins
Blood pressure is low, so valves prevent backflow.
Which blood vessels consist of a single layer of endothelial cells for efficient exchange of substances?
Capillaries
Their thin walls allow diffusion between blood and tissues.
What network of capillaries within a tissue provides a large surface area for exchange?
Capillary bed
Enables efficient transfer of gases, nutrients and wastes.
What fluid surrounds cells and forms when plasma is forced out of capillaries?
Tissue fluid
Formed by hydrostatic pressure at the arterial end of capillaries.
What causes fluid to leave capillaries at the arterial end to form tissue fluid?
High hydrostatic pressure
Driven by hydrostatic pressure exceeding oncotic pressure.